It uses mice to grow hybridoma cells on their peritoneal lining. A. Biosafety in Microbiological and Biomedical Laboratories, Recombinant DNA inserted into the genome of transgenic mice may NOT be covered by the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. The production of polyclonal and monoclonal antibodies in animals is unnecessary in biomedical research. AAALAC International was founded in 1966 and is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. What is a problem that is often encountered with mice housed on wire mesh flooring? Which of the following methods is considered acceptable for euthanizing mice? C. Institutional Animal Care and Utilization Corps B. USDA (Animal Care Section) Which of the following institutions must follow PHS guidelines for animal research? The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? C. For rodents, individual postoperative care records are not usually maintained. C. Health problems in an animal If the funds used to contract for custom antibody production are from the PHS, the IACUC should ascertain that the commercial enterprise has a current Animal Welfare Assurance with the PHS. Institutions receiving PHS money must follow the "Guide" (OLAW oversight) and those accredited with AAALAC are subject to triannual program review and facility visits. With great appre ciation to rese archers, IACUC members, veterinarians, EH&S and IACUC specialists, we announce that AAALAC has finalized their review of UCSFs animal care and A protocol submitted to the IACUC should demonstrate a clear hypothesis driven thought process and a thorough understanding of the number, species, housing and transport requirements of animals proposed for use in research studies. Which of the following statements about identifying mice is NOT true? A. Which of the following applies to doxapram? Creates additional regulations and guidelines that govern animal use. C Category D of the USDA report form applies to " animals upon which experiments, teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic, or tranquilizing drugs were used. Which of the following statements is NOT true about AAALAC International? B As the name implies, the Ag Guide is for agricultural animals used for agricultural (food and fiber) purposes. D Written postoperative care records are kept for individual animals larger than rodents, but written records for groups of rodents are the norm. D. To search for procedures that may replace the use of animals, reduce the number of animals used, or refine the methodology to minimize animal pain or distress. where $x$ is in meters and $t$ is in seconds. A Good practice when performing infectious disease work in animals includes working with hand covers; obtaining an antimicrobial sensitivity panel for the infectious agent; anesthetizing or sedating animals to reduce chances of accidental human needle sticks; and completing work in pairs. A In general, neonates are resistant to low oxygen levels (hypoxia), and accordingly carbon dioxide is not very effective as a euthanasia agent unless there is prolonged exposure. A. Sedation causes vasodilation which helps make the tail vein easier to find. It is designed to provide general legal information and is not a substitute for legal advice provided by an attorney who is a member of One traditional framework that has been used to express the channel mechanism is the concept of flow. D. Nonhuman primates must be enrolled in the program and cannot be exempted. Which statement is true regarding venipuncture procedures in mice: A. Ferrets and cats D The federally mandated search for alternatives helps to fulfill the requirement set forth in the AWA policies to consider alternatives to procedures that may cause more than momentary pain or distress. The attending veterinarian These institutions volunteer to participate in AAALAC's program, in addition to complying with the local, state and federal laws that regulate animal research. Which of the statements concerning blood collection in mice and rats is TRUE? A. Generally there is no need to withhold food or water from mice before surgery because: If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension must be reported by the Institutional Official to OLAW and USDA. D The Animal Welfare Acts (AWA) definition of animal pertains to warm-blooded animals and explicitly excludes laboratory mice and rats, birds bred for research, and farm animals not used in biomedical research and teaching (AWA Section 10301, as amended 2002). Major survival surgery on rodents, non-survival surgery, and major non-survival surgery on non-rodent mammals do not require such a dedicated suite. Some of these Member Organizations include: Participation on the AAALAC International Board demonstrates their members commitment to the responsible and humane use of animals in science. Modify the animal protocol form and keep a copy for their files. A. A new AAALAC service, begun in 1997 and called the Program Status Evaluation, has taken AAALAC representatives to additional countries, where institutions are striving to understand A. It is good to assume that procedures that are painful for humans are also painful for animals. Assist with writing the basic science portions of a grant application All of the following are practical methods of identifying mice EXCEPT: When producing monoclonal antibodies in vivo, what parameter should be considered? Which of the following activities would place an animal in category E? C. A public relations specialist, veterinarian, practicing scientist with experience in animal research, and person who is not a scientist. What potential problem(s) should you be aware of when mice are undergoing surgical procedures? What is the recommended method for the production of monoclonal antibodies? A properly performed search for alternatives will likely also confirm that the animal model is appropriate and that no alternative models exist. Number of animals approved by the IACUC for a particular protocol. To share information with other regulatory agencies Is 12 workers can build a wall in 50 hours how many workers will be required to do the same work in 40 hours? Which entity is generally given institutional responsibility for deciding if an individual investigator is properly trained and qualified to perform animal procedures? C. Sponsors a voluntary accreditation program for animal care and use programs. D. Mice displaying normal behavior can be assumed to be free of pain and distress. Which is TRUE regarding thermal support for mice during anesthesia? Pain or distress in mice is commonly expressed by dramatic changes in activity level and behavior. Pioneers cut bricks from sod-basically, prairie soil as a matrix, and grass and its root system as reinforcement. The IACUC can exempt an animal for scientific reasons. Thermal support is not required in mice during anesthesia. A narrative summarizing experimental data that justifies the use of the proposed animal model. B. Lethal dose experiments in which animals are allowed to die without intervention. B. C. Before any procedures are performed Which measure can correct respiratory depression in anesthetized mice? Which organization is responsible for monitoring institutional compliance with PHS Policy? It requires annual reports from its accredited facilities C. It conducts site visits every 3 years D. It is a government - sponsored agency 16. B. Pre-operative planning is very important. D. Non-vertebrates, laboratory mice, and laboratory rats. D. Major. C. To provide a narrative justifying the use of the animal model based on experimental data. In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). D. Surgery performed under anesthesia. They are methods that are acceptable as a follow-up procedure for ensuring death. Home Flashcards Lab Animal- random IACUC & Short Course questions. More than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International and are represented on the Board of Trustees. C. They become less important Institutions choose to participate in the AAALAC accreditation program for a variety of reasons. B. IACUCs are not responsible for investigating allegations of mistreatment, misuse, or noncompliance, as it is the investigators role to do so. What is the easiest way to induce gas anesthesia for a mouse? https://quizlet.com/393848410/animal-research-certification-test-flash-cards Permission should be obtained from the IACUC and clinical administrators responsible for the area. E. Death from CO2 can be verified solely by a lack of respiration (apnea). What is the age range when mice are weaned? A. Julie S Snyder, Linda Lilley, Shelly Collins, The given equation represents the position of a particle moving along the $x$ axis D. Written postoperative care records are not necessary, as long as proper care is provided and treatments are administered. How are Salmonella spp. Some types of changes to an animal protocol can be approved administratively by veterinary verification and consultation. Which parameter would NOT likely be part of an endpoint policy? The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. In the years that followed, AAALAC accredited hundreds of organizations across the United States, raising the benchmark for laboratory animal care to new heights. Those organizations that sell vertebrate animals for research, teaching, or testing. Which of the following is not a good justification for housing animals individually? A. When assessing a client with partial-thickness burns over 60% of the body, which finding should the nurse report immediately? Which of the following would NOT be accepted by an IACUC as the sole justification for performing multiple major survival surgeries? The Public Health Service (OLAW) Which of the following is true of the nonhuman primate psychological well-being program mandated by the AWR? What is NOT a recommendation for postoperative care of mice? C. Nobody To protect individuals who have frequent contact with animals in a research facility. Minor Members of the Council are chosen to serve based on their extensive experience in the fields of veterinary medicine, laboratory animal science or animal research, and their commitment to humane animal care and use. Long-term anesthesia is best achieved by repeat dosages of a short-acting injectable anesthetic cocktail. A. Weve got your back. 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